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IVIG: Diseases Therapy Can Treat

Intravenous Immunoglobulin Therapy for IVIG Medically Indicated Diseases

Intravenous immunoglobulin therapy is considered medically necessary for a variety of diseases. IVIG treatment provided in the comfort of your own home allows you to have more freedom and a better quality of life. American Outcomes Management (AOM) allows you to be treated for IVIG medically indicated diseases such as diseases of the immune system and neurological system.

IVIG Medically Indicated Diseases Include:

  • Primary Immunodeficiency Diseases - In these types of IVIG medically indicated diseases, the development and maturation of the immune system is affected. Primary immunodeficiency diseases include:
    • Congenital agammaglobulinemia (X-linked agammaglobulinemia)
    • Hypogammaglobulinemia
    • Common variable immunodeficiency
    • X-linked immunodeficiency with hyperimmunoglobulin M
    • Wiscott-Aldrich syndrome
    • Severe combined immunodeficiency
  • Secondary Immunodeficiency Diseases
    • Pediatric AIDS - The late stage of the human immunodeficiency virus
    • Pediatric or Adult HIV Associated Thrombocytopenia
    • B-Cell Chronic Lymphocytic Leukemia (CLL) - A malignancy in which abnormal blood cells invade the body tissue causing lymph-node enlargement and immune dysfunction
    • Allogeneic Stem Cell and Bone Marrow Transplantation - Intravenous immunoglobulin therapy is indicated for hypogammaglobinemic stem cell transplant patients to prevent the risk of acute graft-versus-host disease, associated interstitial pneumonia (infectious or idiopathic) and infections (e.g., cytomegalovirus infections, varicella-zoster virus infection and recurrent bacterial infection) after bone marrow transplantation (BMT).
    • Multiple Myeloma - A malignant disease characterized by the infiltration of bone and bone marrow by neoplastic plasma cells
  • Immune or Idiopathic Thrombocytopenic Purpura (ITP) - A bleeding disorder characterized by a reduction of platelet counts and increased large bone marrow cells
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - A neuromuscular disease characterized by muscle weakness, paralysis, absent reflexes and sensory disturbances
  • Guillain-BarrĂ© Syndrome - An IVIG medically indicated disease that is characterized by Inflammation of multiple nerves with progressive muscular weakness of extremities that may lead to paralysis
  • Multifocal Motor Neuropathy - An IVIG medically indicated disease that affects the nerves and is characterized by asymmetrical motor weakness
  • Kawasaki Disease - An acute, febrile, multisystemic inflammation of the blood vessels that strike predominately newborns and small children.
  • Hemolytic Disease of Newborn - A neonatal disease that is caused by maternal blood incompatibility
  • Secondary Immunosuppression - An IVIG medically indicated disease when associated with:
    • Major surgery (such as cardiac transplants)
    • Hematologic malignancies
    • Extensive burns
    • Collagen-vascular diseases
  • Polymyositis - An inflammatory disease of the skeletal muscles that causes a distinguished rash and proximal muscle weakness
  • Post-Transfusion Purpura - This IVIG medically indicated disease occurs when blood cells leak into the skin or mucous membranes at multiple sited post blood transfusion.
  • Dermatomyositis - A connective tissue disorder marked by swelling, rash, weakness, pain and inflammation of the muscles
  • Myasthenia Gravis - A motor disorder marked by muscular fatigue that develops by repetitive muscle use and improves with rest
  • Moersch-Woltmann (Stiff-man) Syndrome - This IVIG medically indicated disease is characterized by intermittent aching, tightness and stiffness of the muscles, which progresses to permanent stiffness to the extent of limiting voluntary movement.
  • Neonatal Alloimmune Thrombocytopenia (NAIT) - This IVIG medically indicated disease, also known as fetal alloimmune thrombocytopenia, (FAIT) occurs when a pregnant woman produces an alloantibody that reacts with a paternal platelet-specific antigen carried on fetal platelets. The mother is sensitized following a blood transfusion or during pregnancy. The maternal immunolglobulin G (IgG) antibodies cross the placenta and react with the corresponding antigen(s) on fetal platelets resulting in this disease.
  • Parvovirus - A chronic B19 infection with severe anemia
  • Lambert-Eaton Myasthenic Syndrome - A syndrome of muscle weakness, decreased reflexes and autonomic system dysfunction
  • Hyperimmunoglobulinemia E Syndrome - Intravenous immunoglobulin therapy is required for treatment of severe infection.
  • Autoimmune Mucocutaneous Blistering Diseases - IVIG is considered medically necessary for these types of diseases. Patients with pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, mucous membrane pemphigoid (a.k.a., cicatrical pemphigoid) and epidermolysis bullosa acquisita require intravenous immunoglobulin therapy if they have either failed or have had contraindications to conventional therapy. Patients who have rapidly progressive diseases in which a clinical response could not be affected quickly enough using conventional agents also require IVIG treatment. When indicated for rapidly progressive diseases, accepted guidelines indicate that IVIG should be given along with conventional treatment(s) and IVIG should be used only until conventional therapy can take effect.
  • Multiple Sclerosis - This disease requires IVIG treatment. It is characterized as a chronic disease of the central nervous system in which there is destruction of the nerves in the brain and spinal cord. There are different classifications of MS varying in severity.
  • Systemic lupus Erythematosus (SLE) - Chronic inflammatory disease of the connective tissue, which affects the skin, joints, kidneys, mucous membranes and nervous system
  • IgG Deficiencies - Selective IgG subclass deficiencies with severe infection for persons meeting selection criteria require intravenous immunoglobulin therapy.
  • Renal Transplant - Intravenous immunoglobulin therapy is required for renal transplant patients who have received the transplant from a live donor with ABO incompatibility or positive cross-match where a suitable non-reactive live or cadaveric donor is unavailable (preparative regimen).
  • Churg-Strauss Syndrome (CSS) - A rare systemic vasculitis affecting the respiratory, musculoskeletal, cardiac and nervous system
  • Refractory Autoimmune Hemolytic Anemia
  • Toxic Shock Syndrome - IVIG treatment is required for diseases such as toxic shock syndrome or toxic necrotizing fasciitis due to group A streptococcus.

For more information on IVIG medically indicated diseases, please visit our IVIG FAQs or contact us at 1-800-746-9089. Press zero to speak to an AOM staff member 9am-5pm, Monday through Friday. We will be happy to answer all of your questions about AOM and our intravenous immunoglobulin therapy.

If you are a physician and would like to refer a patient to AOM for intravenous immunoglobulin therapy, please contact us at 1-800-746-9089.